张默博士-副教授
发布时间：2019-10-30 浏览次数：0次
张默，副教授，硕士生导师。2022年6月毕业于北京理工大学，并于同年9月入职探花系列 。研究方向集中于药物创新给药体系的构建和多酸基纳米材料的生物应用。主持国家自然科学基金青年基金，中国博士后基金，河北省优秀青年基金，河北省高等学校科学技术青年拔尖项目和河北省博士后择优资助项目。入选2024年全球前2%顶尖科学家，现任Eur. Cells Mater.、Biomater. Transl.、Exploration等期刊青年编委。目前以第一作者/通讯作者在Angew. Chem. Int. Ed.; Bioact. Mater.; ACS Catal.等权威期刊上发表论文30余篇。
主持项目情况:
1. 国家自然科学基金青年基金，多钼氧酸盐@共价有机框架复合物的构筑及抗肿瘤研究，2024/01-2026/12，20301060，30万。
2. 中国博士后科学基金特别资助，多酸基羟基磷灰石/壳聚糖复合材料多模式联合促进骨折愈合及机制研究，2022/12-2024/12，2023TQ0103，18万。
3. 中国博士后科学基金面上项目，以激活BMP/Samd信号通路为靶点的多酸基水凝胶复合材料促进骨折愈合研究，2022/12-2024/12，2023M730914，8万。
4. 河北优秀青年基金项目，多金属氧酸盐基核/壳水凝胶在骨肉瘤性骨缺损修复中的作用及机制研究，2025/1-2027/12，H2025206446，20万。
5. 河北省高等学校科学技术青年拔尖项目，以激活细胞焦亡通路为靶点的多酸基纳米胶束构建及抗肿瘤研究，2024/01-2026/12，BJK2024190，10万。
近五年发表论文情况：
1.Mo Zhang, Siao Yang, Mengxuan Liu, Yawen Chen, Qingqing Dou, Ruoqing Jia, Wei Chen*, Zhengguo Lin*, Jing Wang*, Changwen Hu. Tungstotellurate(VI)-based nanocomposite inhibits breast cancer proliferation and metastasis by enhancing cuproptosis and apoptosis. Angew. Chem. Int. Ed. 2025, e202514795.
2.Xiaoxiao Hu, Qingqing Dou, Peixiao Jiang, Mo Zhang*, Jing Wang*. Targeting matrix metalloproteinases activating and indoleamine 2,3-dioxygenase suppression for triple-negative breast cancer multimodal therapy. Int. J. Biol. Macromol. 2025, 310, 143289.
3.Mo Zhang, Fan Xu, Jingcheng Cao, Qingqing Dou, Juan Wang, Jing Wang, Lei Yang*, Wei Chen*. Research advances of nanomaterials for the acceleration of fracture healing. Bioact. Mater. 2024, 31, 368-394.
4.Xiaoxiao Hu#, Mo Zhang*,#, Cuilu Quan, Saisai Ren, Wei Chen*, Jing Wang*. ROS-responsive and triple-synergistic mitochondria-targeted polymer micelles for efficient induction of ICD in tumor therapeutics. Bioact. Mater. 2024, 36, 490-507.
5.Yao Zhang#, Mo Zhang#, Xiaoxiao Hu, Han Hao, Cuilu Quan, Tiantian Ren, Huile Gao*, Jing Wang*. Engineering a porphyrin COFs encapsulated by hyaluronic acid tumor-targeted nanoplatform for sequential chemo-photodynamic multimodal tumor therapy. Int. J. Biol. Macromol. 2024, 279, 135328.
6.Mi Wang#, Mo Zhang#, Jianyi Bi, Jincan Li, Xiaoxiao Hu, Lina Zhang, Yao Zhang, Wenli Wang, Yuan Lin, Hong-Bo Cheng,* and Jing Wang*. Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy. ACS Appl. Mater. Interfaces 2024, 16, 18252-18267.
7.Siao Yang, Xiaoxiao Hu, Zhengze Yong, Qingqing Dou, Cuilu Quan, Hong-Bo Cheng, Mo Zhang*, Jing Wang*. GSH-responsive bithiophene Aza-BODIPY@HMON nanoplatform for achieving triple-synergistic photoimmunotherapy. Colloids Surf., B 2024, 242, 114109.
8.Mo Zhang, Zheng Li, Yeqin Feng, Xing Xin, Guo-Yu Yang* and Hongjin Lv*. Highly selective hydrogenolysis of lignin β-O-4 models by a coupled polyoxometalate/CdS photocatalytic system. Green Chem., 2023, 25, 10091.
9.Mi Wang#, Mo Zhang#, Xiaoxiao Hu, Wenli Wang, Yao Zhang, Lina Zhang, Jing Wang*, Lipid-functionalized gold nanorods with plug-to-direct mitochondria targeting ligand for synergetic photothermal-chemotherapy of tumor therapy. Eur. J. Pharm. Biopharm. 2023, 185, 71-81.
10.Mo Zhang, Xing Xin, Yeqin Feng, Junhao Zhang, Hongjin Lv*, and Guo-Yu Yang*. Coupling Ni-substituted polyoxometalate catalysts with water-soluble CdSe quantum dots for ultraefficient photogeneration of hydrogen under visible light. Appl. Catal. B: Environ. 2021, 333, 120893.
11.Mo Zhang, Huijie Li, Junhao Zhang, Hongjin Lv*, Guo‐Yu Yang*. Research advances of light‐driven hydrogen evolution using polyoxometalate‐based catalysts. Chin. J. Catal. 2021, 42, 855-871.
12.Mo Zhang, Zheng Li, Xing Xin, Junhao Zhang, Yeqin Feng, and Hongjin Lv*. Selective valorization of 5 hydroxymethylfurfural to 2,5-diformylfuran using atmospheric O2 and MAPbBr3 perovskite under visible light. ACS Catal. 2020, 10, 14793-14800.